The aim of this study was the comparison of the concentration of two major growth factors, platelet derived growth factor BB (PDGF-BB) and vascular endothelial growth factor (VEGF), in two platelet concentrates (PC), concentrated growth factor (CGF) and platelet rich plas ma (PRP), as well as the evaluation of the age effect in their concentrations. PRP is a well-studied platelet concentrate with very high con gregations of active blood components crucial for Regenerative Endodontic Procedures (REP). CGF has been found to promote the in vitro proliferation, migration and differentiation of stem cells of apical papilla, but it has not been used clinically, yet. Twenty healthy individuals participated in this study, in two age groups, 20-30 and 40-50 years old. 10 ml of venous blood was drawn from each participant, 5ml of which was stored with anticoagulant agent in order to prepare the PRP and the rest 5ml were immediately centrifuged to prepare the CGF. All specimens were stored at sterile Eppendorf tubes at -80°C. PDGF-BB and VEGF levels were identified using ELISA kits and the results were used for statistical analysis, by using SPSS Statistics. PDGF-BB levels were higher in PRP than in CGF of the same donor, though VEGF show no significant difference. According to this study PRP contains higher concentration of PDGF-BB compared to CGF, but there is no signifi cant difference between the levels of VEGF. Growth factor levels do not seem to have important differences between the two age groups